Permender Rathee, Anjoo Kamboj and Shabir Sidhu Pages 50 - 62 ( 13 )
Objective: The aim is to describe the role and function of polymer or peptide mediated drug delivery system considerations in Nano-formulations.
Background: The Polymers are the basic frameworks of any formulation, more importantly in case of Sustained/controlled release or Nano-particulate forms. The most commonly used polymers composed of PLA (Poly Lactic Acids).
Methods: A systematic search of the published literature was performed by using MEDLINE, EMBASE, the Cochrane Library and Patent Databases.
Results: More than 20 patents and 60 research and review papers were selected and studied in which PLA’s had been used as a formulating agent. The data from literature was transformed in tabular forms for better comparison and understanding of role and function of polymer or peptide mediated drug delivery system considerations.
Conclusion: These transformations usually aid to achieve the desired in-vivo biological activity by protecting the molecule’s first pass metabolism and overcoming toxicity. Moreover, these peptide polymer conjugates have numbers of biomedical remedy applications in the various disorders. These poly-peptide conjugates have been approved by the World Health Organization (WHO) and the Food and Drug Administration (FDA) as materials that can be used in medicine/pharmaceutical delivery vehicles.
Applications, bio-medical, peptides, poly-(meric)-acids, polymers, therapeutic.
Department of Life Sciences and Technology, IKGPTU, Kapurthala, India