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Shaping and Cellular Uptake of Folic Acid Coated Gold and Magnetite Nanoparticles

[ Vol. 9 , Issue. 2 ]

Author(s):

Ahmed A.G. El-Shahawy*, Gamal Elghnam and Alsayed A.M. Alsherbini   Pages 166 - 172 ( 7 )

Abstract:


Background: Gold and Iron Oxide nanoparticles NPs play as nanocarriers for a specific drug delivery and contrast agents. Intercellular uptake of these nanoparticles and targeting to individual cell and sub-cellular compartment is essential.

Objective: The aim of the current study is to evaluate the intracellular uptake of these NPs to specific tumor cells in vitro conjugated with folic acid with a goal of enhancing the efficiency of specific targeting to tumor cells.

Methods: We synthesized the nanoparticles by a chemical method and characterized by UV-Visible, FTIR, XRD, and TEM.

Results & Conclusion: The results revealed the conjugation of Gold and Iron Oxide nanoparticles with folic acid increased the intercellular uptake with high percent compared to non- conjugated nanoparticles.

Keywords:

Gold, Iron oxide nanoparticles, folate receptors, intracellular uptake, folic acid, magnetite nanoparticles.

Affiliation:

Materials Sciences and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences PSAS, Beni-Suef University, Bani Suwayf, Photochemistry and Photobiology Department, National Institute of Laser Enhanced Science (NILES), Cairo University, Bani Suwayf, Photochemistry and Photobiology Department, National Institute of Laser Enhanced Science (NILES), Cairo University, Bani Suwayf

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