Sweta Garg, Ashish Garg, Sreenivas Enaganti and Awesh K. Yadav* Pages 243 - 261 ( 19 )
Background: Currently, cancer is rising as one of the dominant causes of human deaths worldwide. The application of nano-carriers may help to treat cancer through the delivery of anticancer drugs inside the tumor cells.Objective: The foremost objective behind this research was to formulate chondroitin sulfate tailored cellulose acetate phthalate (CSAC) core shield nanoparticles (NPs) containing 5-Fluorouracil (5-FU) as an anticancer drug. Methods: The FTIR and 1H-NMR spectroscopic methods were used to analyze and characterize the formulation of CSAC copolymer. NPs were typified by Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), Atomic Force Microscopy (AFM), Entrapment efficiency and in-vitro drug release. Results: CSAC NPs were found to exhibit moderate release (95.59±0.15% in 34hrs) than CAP NPs (78.97±0.08% in 8 hours). In the course of cytotoxicity examination in A549 cancer cell line, the results revealed that these 5-FU loaded CSAC NPs showed an immense cytotoxic potentiality. Moreover, CSAC NPs exhibit least hemolytic activity when compared with CAP NPs and plain 5-FU. Conclusion: Conclusively, it was found that the CSAC NPs is an efficient carrier system for the better release of 5-FU in lung cancer.
Nanoparticles, 5-fluorouracil, cellular cytotoxicity, chondroitin sulfate, cellulose acetate phthalate, lung cancer.
RKDF College of Pharmacy, SRK University, Bhopal, (MP) 462026, RKDF College of Pharmacy, SRK University, Bhopal, (MP) 462026, Bioinformatics division, Averin Biotech Pvt. Ltd., Nallakunta, Hyderabad, Telangana, 500044, Drug Delivery and Nanotechnology Laboratories, Department of Pharmaceutics, Bhagyoday Tirth Pharmacy College, Sagar (MP), 470001