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Fate and Applications of Superporous Hydrogel Systems: A Review

[ Vol. 10 , Issue. 4 ]

Author(s):

Vikas Jhawat*, Monika Gulia, Balaji Maddiboyina, Rohit Dutt and Sumeet Gupta   Pages 326 - 341 ( 16 )

Abstract:


Hydrogels are a class of biomaterial that can “take in” large quantities of aqueous media and swells many times larger than its original size without dissolving in the media. SPHs are a new generation of hydrogels containing a 3D network of cross-linked polymers having pore size more than 100 μm as compared to 10 nm to 10 μm pores of conventional gels. These are more complex in nature than conventional hydrogels and prepared by using a suitable blend of monomers and different additives. SPHs have been extensively employed in sustained and control drug delivery systems along with many recent biomedical applications such as in tissue engineering, immunotherapy, arthritis and ophthalmic drug delivery. Scientists are constantly working on improving the features and properties of SPHs to enable them more suitable for therapeutic and biomedical applications. The present study briefly reviews the composition, evaluation and applications of SPHs in different areas. Applications are facilitated by the fact that SPHs are generally biocompatible in nature and resemble natural living tissue more than any other class of synthetic biomaterial.

Keywords:

Biocompatible polymers, biodegradable polymers, biomedical, polymer gels, superporous hydrogel, therapeutic.

Affiliation:

Department of Pharmaceutical Science, School of Medical and Allied Science, GD Goenka University, Gurugram, Haryana, Department of Pharmaceutical Science, School of Medical and Allied Science, GD Goenka University, Gurugram, Haryana, Department of Pharmaceutics, Vishva Bharathi College of Pharmaceutical Sciences, Guntur, Andhra Pradesh, Department of Pharmaceutical Science, School of Medical and Allied Science, GD Goenka University, Gurugram, Haryana, Department of Pharmaceutical Sciences, MM College of Pharmacy, Mullana, Ambala, Haryana

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